Osteoarthritis

Interrupt the Vicious Circle of Aggravation in Osteoarthritis

Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the articular cartilage, subchondral bone, ligaments, capsule and synovium. OA was considered a wear and tear mechanical disease but now it is understood that the cross-talk between various joint structures and local inflammation is a central aspect of the underlying pathophysiology. In vivo and in vitro studies have shown various physiological effects of exogenous hyaluronic acid (HA) that can enhance chondrocyte synthesis of endogenous HA and proteoglycans, prevent the degradation of cartilage and promote its regeneration.

Modern Medicine – Issue 1 2024

Hyaluronic Acid: A Lasting Treatment for Osteoarthritic Joints

Osteoarthritis is a chronic degenerative joint disease characterised by pain and progressive functional limitation. Viscosupplementation with intra-articular hyaluronic acid is a treatment option in knee OA that is included in various professional guidelines for the treatment of this joint disease, but potentially could apply to all synovial joints in order to reduce pain and improve joint lubrication.

Modern Medicine – Issue 6 2021

Osteoarthritis, Moving Beyond Ageing

Osteoarthritis is a heterogeneous group of diseases characterised by pain and loss of function, and is a leading cause of disability worldwide. Although risk factors vary across joints, common factors include obesity and advancing age. A largely clinical diagnosis, management for symptomatic disease is centred on nonpharmacological and nonsurgical measures. Pharmacotherapy is ideally limited to the treatment of acute flares of pain with joint replacement being reserved for advanced symptomatic disease.

Modern Medicine – Feb/March 2019