Neurology

The Physiology of Chronic Pain The Role of the Inhibitory Interneuron

The Physiology of Chronic Pain The Role of the Inhibitory Interneuron – MM1401

As described in the original article in May 2013, central sensitisation of the dorsal horn cells with facilitated pain processing and transmission can occur after nerve injury, deafferentation of the spinal cord (amputation or nerve section) or due to afferent barrage.
As a result, anatomical and neuro-chemical changes can occur within the central nervous system (CNS) that can persist long after the injury has healed.
This ‘CNS plasticity’ may play an important role in the evolution of chronic, neuropathic pain. The sensitisation of neurons that occurs within the dorsal horn results in spontaneous activity of the dorsal horn neurons, a decreased threshold and an increased responsivity to afferent input, and cell death in the spinal dorsal horn. The cells that die are the inhibitory interneurons.

Modern Medicine – January 2014

January 21, 2014 by Peter Neurology Pain

Investigating a Seizure: Is it Epilepsy

Investigating a Seizure: Is it Epilepsy – MM1306

Epileptic seizures have varied symptoms and many paroxysmal events can be imitators of epileptic attacks. A detailed eyewitness report of the patient’s behaviour during a seizure can be a valuable diagnostic tool.

Modern Medicine – June 2013

June 11, 2013 by Peter Epilepsy Neurology Seizure

Transient Neurological Troubles in Patients with Type 2 Diabetes

Transient Neurological Troubles in Patients with Type 2 Diabetes – MM1305

Transient neurological attacks, early warning signs of cerebrovascular disease, are usually differentiated by their history. As type 2 diabetes is an important risk factor for a transient ischaemic attack (TIA) and subsequent stroke,
this article focuses on the acute, usually urgent management of this focal transient neurological problem and its prevention.

Modern Medicine – May 2013

May 14, 2013 by Peter Cardiology Diabetes Neurology Stroke

Therapeutic Progress in Parkinson’s Disease

Therapeutic Progress in Parkinson’s Disease – MM1303

Pharmacological dopamine replacement is the most effective form of treatment for patients with early Parkinson’s disease. However, it is only a symptomatic therapy. Future therapeutic strategies should therefore focus not only on ameliorating the symptoms of Parkinson’s disease, but on neuroprotective or neurorescue therapies.

Modern Medicine – March 2013

April 24, 2013 by Peter Dementia Neurology

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