Ivy Leaf Extract Effective for Treating Airway Diseases – MM1605
Preparations from ivy leaves (Hederae helicis folium, Hedera helix) dry extracts are well established in the treatment of different respiratory diseases. Their efficacy and safety have been demonstrated in a variety of controlled clinical and non-interventional studies. The effect of ivy leaves dry extract is based on its secretolytical and broncholytical properties. The main active compounds are saponins and especially α-hederin represents the most important saponin molecule responsible for the therapeutic effect.
It has been shown that α-hederin prevents β2-adrenergic receptors from internalisation and enables a higher number of receptors to be activated by the endogenous ligand adrenaline.6 As a consequence, a higher grade of bronchodilation and surfactant production is achieved, leading to the bronchospasmolytic, secretolytic, expectorant and, in turn, antitussive effect of ivy leaves extract preparations.
Modern Medicine – May 2016
