Biomarkers Aid Early Diagnosis of Alzheimer’s – MM1505
Alzheimer’s disease (AD) is a chronic neurodegenerative disease with well-defined pathophysiological mechanisms, mostly affecting medial temporal lobe and associative neocortical structures. Neuritic plaques and neurofibrillary tangles represent the pathological hallmarks of AD and are respectively related to the accumulation of the amyloid-beta peptide (Aβ) in brain tissues and to cytoskeletal changes that arise from the hyperphosphorylation of microtubule-associated Tau protein in neurons.
Modern Medicine – May 2015
