Diuretic Resistance, a Factor in Chronic Kidney Disease – MM1605
Diuretics exert their effects via the kidney, relying on secretion, and to a minor degree on glomerular filtration, to achieve therapeutic concentrations in the tubule. Diabetes and atherosclerosis can both cause glomerular damage and glomerulosclerosis, affecting glomerular filtration rate (GFR), while the Renin-Angiotensin system activation and inflammation common to both conditions also contributes to a reduced response.
Modern Medicine – May 2016
