Osteoarthritis Factors Associated with Pain and Implications for Therapy – MM1608
Osteoarthritis is an umbrella term for several processes that lead to pain and cartilage loss. X-rays give limited information and only provide marginal assistance at tailoring therapy for the individual. MRI has great potential in this regard but targeted trials have been few to date. Bone marrow lesions and cartilage defects have independent associations with pain in people with osteoarthritis. Obesity and weak muscles are also independently associated with pain in osteoarthritis; therefore, weight loss, strengthening and aerobic exercises help improve symptoms. Pain in osteoarthritis is modified by central factors such as depression, catastrophisation, self-efficacy and a positive attitude. Targeting subchondral bone has the most potential to modify osteoarthritis given the failure of most therapies aimed at cartilage.
Modern Medicine – August 2016
