Improving Lipid Profiles with Fenofibrate – MM1704
Fibric acid derivatives (fibrates) are effective antilipidemic agents with peroxisome proliferator–activated receptor
agonist activity and are indicated for the treatment of severe hypertriglyceridaemia and mixed dyslipidaemia in patients who
have not responded to nonpharmacological therapies. Fibrates also have nonlipid, pleiotropic effects (eg, reducing
levels of fibrinogen, C-reactive protein and various proinflammatory markers and improving flow-mediated dilatation)
that may contribute to its clinical efficacy, particularly in terms of improving microvascular outcomes.
Modern Medicine – April 2017
