Interrupt the Vicious Circle of Aggravation in Osteoarthritis
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the articular cartilage, subchondral bone, ligaments, capsule and synovium. OA was considered a wear and tear mechanical disease but now it is understood that the cross-talk between various joint structures and local inflammation is a central aspect of the underlying pathophysiology. In vivo and in vitro studies have shown various physiological effects of exogenous hyaluronic acid (HA) that can enhance chondrocyte synthesis of endogenous HA and proteoglycans, prevent the degradation of cartilage and promote its regeneration.
Modern Medicine – Issue 1 2024
