Fibrate Therapy for Dyslipidaemia and Prevention of Cardiovascular Disease – MM1410
The main use of fibrates is for the treatment of dyslipidaemia to lower plasma triglyceride levels and to raise HDL-cholesterol (HDL-C) levels. The effects of fibrates on LDL-cholesterol levels vary. Fibrates may be used either as monotherapy or in combination with statins. When combined with statins, fenofibrate is the preferred fibrate as it has a low risk of myopathy. The benefits of fibrate therapy in preventing ischaemic cardiovascular disease events appear to be confined to patients with baseline dyslipidaemia (raised triglyceride levels and/or low HDL-C levels).
Modern Medicine – October 2014
