Dopamine and Noradrenaline Reuptake – MM1504
The mechanism of action of bupropion is still uncertain but may be related to inhibition of presynaptic dopamine and noradrenaline reuptake transporters. The activity of vesicular monoamine transporter-2, the transporter pumping dopamine, noradrenaline and serotonin from the cytosol into presynaptic vesicles, is increased by bupropion and may be a component of its mechanism of action. Bupropion is approved for use in major depression and seasonal affective disorder and has demonstrated comparable efficacy to other antidepressants in clinical trials.
Modern Medicine – April 2015
